Zane R. Lybrand, Ph.D.

Contact

ZLybrand@twu.edu
940-898-2192
Scientific Research Commons 304J

Website

Biography

Dr. Lybrand is a neuroscientist and cell biologist who specializes in neurophysiology, stem cell biology, and brain health. Research in his lab uses stem cells to understand endogenous mechanisms for brain injury and to develop therapies for regenerative medicine to treat traumatic brain injuries (TBI). He currently teaches Anatomy and Physiology.

Education

Ph.D., Zoology, Texas A&M University, College Station, Texas
B.S., Psychology, Texas A&M University, College Station, Texas

Research Interests

Neuroscience; Brain Health; Regenerative Medicine; Traumatic Brain Injury; TBI; Epilepsy; Stem Cells; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Electrophysiology; Neurophysiology

Latest Articles

Modern in vitro techniques for modeling hearing loss.
Bioengineering (2024)
Zane Lybrand

Understanding primary blast injury: High frequency pressure acutely disrupts neuronal network dynamics in cerebral organoids
Journal of Neurotrauma (2022)
Zane R Lybrand, Marc Joshua Silvosa, Nohemi Romo Mercado, Nikolas Merlock, Suhas Vidhate

A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
Nature Communications (2021)
Zane Lybrand, S Goswami, J Zhu, V Jarzabek, H Hsieh

Novel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability
Frontiers in Neuroscience (2021)
Parul Varma, Zane R Lybrand, Mariah C. Antopia, Jenny Hsieh

Coupled sensory interneurons mediate escape neural circuit processing in an aquatic annelid worm, Lumbriculus variegatus.
Journal of Comparative Neurology (2020)
Zane R Lybrand, Veronica G Martinez-Acosta, Mark J Zoran

Stem cells: a path towards improved epilepsy therapies.
Neuropharmacology (2020)
Zane Lybrand, Sonal Goswami, Jenny Hsieh

Deep Blue 'Seq': Fishing for Epilepsy Genes
Epilepsy Currents (2016)
Zane Lybrand, Jenny Hsieh

Aberrant hippocampal neurogenesis is critical for epilepsy and associated cognitive decline.
Nature Communications (2015)
Kyung-Ok Cho, Zane R Lybrand, Naoki Ito, Rebecca Brulet, Jenny Hsieh

Current Projects

Neurobiology of traumatic brain injury. During TBI, multiple types of mechanical forces can cause tissue damage or disrupt brain function that ultimately leads to neurological impairment. The Lybrand lab focuses on understanding how pressure, shear stress, and cavitation forces disrupt the neural circuitry of the brain.
Brain regeneration. The brain has a limited ability to regenerate and repair itself. We use stem cell technology to build brain tissue grafts for transplantation that can regenerate damaged neural pathways and functionally recover disabilities caused by TBI.

Externally Funded Projects

Developing stem cell derived cortical grafts for brain regeneration in TBI Year 1 of 2
Mission Connect | $50,000.00 | 2024
Role: Principal Investigator

Development of Human-Based Cochlea-on-a-Chip for Auditory Exposure Year 2 of 3
GOV-Department of Defense (DD) | $150,000.00 | 2024
Role: Co-Principal Investigator

Multi‐electrode array system for mapping neural network dynamics from human cerebral organoids following exposure to forces associated with blast and blunt trauma
GOV-Office of Naval Research (ONR) | $149,633.00 | 2022
Role: Principal Investigator

Temporal and physiological changes in cerebral organoids after increasing pulsed radiofrequency wave exposure
GOV-Department of Defense (DD) | $150,000.00 | 2022
Role: Co-Principal Investigator

Temporal & Physiological Changes in Cerebral Organoids after Increasing Pulsed RF Wave Exposure
GOV-Department of Defense (DD) | $89,870.00 | 2021
Role: Principal Investigator

Internally Funded Projects

Understanding DLG4 Mutations and Their Impact on Neurodevelopmental Disorders
GOV-Texas Woman's University | $10,000.00 | 2024
Research Grant