Tina Gumienny, Ph.D.

Contact

TGumienny@twu.edu
940-898-2295
SRC 304H

Biography

Education

Ph.D., State University of New York; B.S., Texas A&M University

Interests

Biology; Advanced Genetics; Cell Communication

Education

Ph.D., State University of New York at Stony Brook
B.S., Genetics, Texas A&M University, College Station, Texas

Research Interests

Biology; Advanced Genetics; Cell Communication

Latest Articles

The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans
eLife (2023)
Bhoomi Madhu, MF Lakdawala, Tina L. Gumienny

Small-scale extraction of Caenorhabditis elegans genomic DNA
Journal of Visualized Experiments (2022)
B Madhu, M. F. Lakdawala, T L Gumienny

Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity
Aging Cell (2022)
S. L.B. Arneaud, J. McClendon, L. Tatge, A. Watterson, K. R. Zuurbier

Establishing C. elegans as a model to study the function of vitamin A metabolism
TWU Student Journal (2021)
P Joseph, H Everts, T Gumienny

The DBL-1/TGF-β signaling pathway regulates pathogen-specific innate immune responses in C. elegans
bioRxiv (2021)
B Madhu, T L Gumienny

Caenorhabditis elegans saposin-like spp-9 is involved in specific innate immune responses
Genes and Immunity (2020)
B Madhu, M F Lakdawala, N G Issac, T L Gumienny

Loss of dpy-2 and dpy-9 has stage-specific effects on DBL-1 pathway signaling
microPublication Biology (2019)
M. F Lakdawala, Tina L Gumienny

Genetic interactions between the DBL-1/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans
Molecular Biology of the Cell (2019)
M F Lakdawala, B Madhu, L. Faure, M. Vora, R. W. Padgett

Caenorhabditis elegans egg-laying and brood-size changes upon exposure to Serratia marcescens and Staphylococcus epidermidis are independent of DBL-1 signaling
microPublication Biology (2019)
B. J. Madhu, A. E. Salazar, Tina L Gumienny

Feedback regulation of BMP signaling by C. elegans cuticle collagens
bioRxiv (2019)
U. Madaan, L. Faure, A. Chowdhury, S. Ahmed, E. J. Ciccarelli

Feedback regulation of BMP signaling by Caenorhabditis elegans cuticle collagens
Molecular Biology of the Cell (2019)
U. Madaan, L. Faure, A. Chowdhury, S. Ahmed, E. J. Ciccarelli

The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans
Cell Death and Differentiation (2018)
S D King, C F Gray, Tina L Gumienny

Determining how TGF-β is trafficked and secreted in C. elegans
Texas Journal of Microscopy (2018)
G. Ravindranathan, L. Faure, Tina L Gumienny

Regulation of Extracellular Matrix in C. elegans: Lessons in Sweating the Small Stuff
Proc Microsc Microanal (2018)
R.D Schultz, Tina L Gumienny

Fast and inexpensive C. elegans genomic DNA preparation using Sigma's Extract-N-Amp kit
The Worm Breeder's Gazette (2016)
B. Madhu, Tina L Gumienny

The Caenorhabditis elegans p38 MAPK gene plays a key role in protection from mycobacteria.
MicrobiologyOpen (2016)
T. Galbadge, T.F. Sheperd, S.L. Cirillo, Tina L Gumienny, J.D. Cirillo

Novel regulated secretion mechanism for a nerve-secreted cell-cell signaling molecule in C. elegans
Microsc Microanal (2015)
R. D. Schultz, K Beifuss, S Taneja-Bageshwar, Tina L Gumienny

Current Projects

I am interested in how cells communicate with each other at the molecular and cellular levels during development. My group focuses on Transforming Growth Factor-ß superfamily members (TGF-ßs), critical messengers for intercellular communication in metazoans. My long-term research goal is to understand how proper cell-to-cell signaling by TGF-ß is achieved during development and can be disrupted in disease states. Specifically, we study the molecular players and processes involved in regulating these signals in the nematode model system C. elegans using genetic, molecular, cell imaging, and biochemical tools.

Externally Funded Projects

Development and characterization of a Myhre Syndrome nematode model
GOV-National Institutes of Health(NIH) | $3,250.00 | 2024
Role: Principal Investigator

Investigation of the Biochemical Composition and Molecular Mechanisms of Roundworm Epicuticle Formation to Identify Novel Target Proteins for Anthelmintic Drug Development Year 2 of 2
United States Department of Agriculture, Agriculture and Food Research Initiative | $100,000.00 | 2018
Role: Principal Investigator

Chromatin condensation as a DNA protective response to UV radiation in human melanocytes and aging C. elegans Year 2 of 2
GOV-National Institute on Aging (NIA) | $50,000.00 | 2018
Role: Principal Investigator

Determining the physiological effect of developmental RAB-1 and MAP2 loss in the C. elegans model system
Scottish Rite Hospital for Children | $6,061.00 | 2018
Role: Principal Investigator

Investigation of the Biochemical Composition and Molecular Mechanisms of Roundworm Epicuticle Formation to Identify Novel Target Proteins for Anthelmintic Drug Development Year 1 of 2
GOV-Department of Agriculture (USDA) | $100,000.00 | 2018
Role: Principal Investigator

National Institute of General Medical Sciences R01 Year 5 of 5
GOV-National Institutes of Health(NIH) | $1,082,275.00 | 2016
Role: Principal Investigator

Internally Funded Projects

Travel funds to attend the 24th International C. elegans Conference, Glasgow, UK
Jane Nelson Institute for Women's Leadership | $3,910.00 | 2023
Research Grant

Tissue-specific regulation of a cell-signaling pathway by a family of protein-cutting enzymes
Jane Nelson Institute for Women's Leadership | $23,560.00 | 2021
Research Grant

Defining the molecular interaction of the DBL-1/BMP signaling pathway with BLMP-1/BLIMP1 in Caenorhabditis elegans
Research Enhancement Program | $10,000.00 | 2020
Research Grant

Role of a cell signaling pathway in mounting protective responses against different bacterial immune challenges in the roundworm model organism C. elegans
Texas Woman's University | $10,000.00 | 2019
Research Grant

Proposal Wages For Student Assistants
$6,540.00 | 2018
Research Grant

2017 Summer Research Initiative
GOV-Texas Woman's University | $6,540.00 | 2017
Research Grant

New Investigator Research Enhancement Program (REP) Grant
GOV-Texas Woman's University | $10,000.00 | 2017
Research Grant

TWU Innovation Proposal
GOV-Texas Woman's University | $65,262.00 | 2016
Research Grant

Small Grants Program
GOV-Texas Woman's University | $761.00 | 2016
Research Grant

Teaching and Research Grant for Equipment and Technology (TARGET) Grant
GOV-Texas Woman's University | $291,233.00 | 2015
Research Grant

New Investigator Research Enhancement Program (REP) Grant
GOV-Texas Woman's University | $10,000.00 | 2015
Research Grant