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Anderson, Mary, Ph.D., Assistant ProfessorAnderson, Mary, Ph.D., Associate Professor

B.A. in Chemistry, Hollins College
Ph.D. in Biochemistry, Cornell University Graduate School of Medical Sciences
 
Office:  GRB 331
Phone:  940.898.2564
Lab:    ASSC 332
email:  MAnderson3@mail.twu.edu
 
Primary Teaching Area: Biochemistry
 
Research Interests: My research team study enzymes, mainly the homodimeric glutathione synthetase, important in the biosynthesis of the body’s most important natural antioxidant, glutathione. Experimental and computational techniques are integrated to understand how this key enzyme works. Glutathione protects against many things (toxins and aging). Diseases such as HIV, Parkinson’s and Alzheimer’s are associated with glutathione deficiencies. My research team (undergraduate and graduate students) work on increasing knowledge of protein-protein interactions, designing better enzymes and therapies for glutathione deficiency.


Britt, Mark, Ph.D., Associate Professor

B.S. in Chemistry, Millsaps College
Ph.D. in Chemistry, University of Oregon
 
Office: GRB 203B
Telephone: 940.898.2566
Lab:    GRB 203
email: MBritt@mail.twu.edu
 
Primary Teaching Area:Physical Biochemistry
 
Research Interests:Our research investigates the role played by the bulk enzyme structure in the enzyme catalytic event.  Specifically we are testing a hypothesis, the Shifting Specificity Model, to explain enzyme catalysis generally.  Our experiments involve kinetic and thermodynamic measurements of interactions of enzymes with catalytically relevant ligands.


Gill, Jack T., Ph.D., Professor

Gill, Jack T., Ph.D., Professor

B.S. in General Science - Chemistry, Mississippi State University
Ph.D. in Organic Chemistry, Mississippi State University

Office: ASSC 329
Telephone: 940.898.2662
Lab:    SCI 213B
email: JGill@mail.twu.edu

Primary Teaching Area: General Chemistry

Research Interests: Chemical Education


Johnson, James E., Ph.D., Professor

Johnson, James E., Ph.D., Professor

B.S. in Chemistry, University of Minnesota
M.S. in Chemistry, University of Minnesota
Ph.D. in Organic Chemistry, University of Missouri, Columbia

Office: GRB 103
Telephone: 940.898.2567
Labs:   GRB 108, 112, 205, 211, 213, and 215
email: JJohnson@mail.twu.edu

Primary Teaching Area: Organic Chemistry

Research Interests: Chemistry of organic nitrogen compounds: mechanisms of nucleophilic substitution reactions on the carbon-nitrogen double bond; mechanisms of Z/E isomerization of compounds containing a carbon-nitrogen double bond (photochemical, thermal, acid- and base-catalyzed); synthesis of hydroximoyl halides, hydroximates, thiohydroximates, amidoximes, oximes, and other compounds containing a carbon-nitrogen double bond; photochemical reactions of amides, alkyl benzohydroxamates, and other structurally related organic nitrogen compounds;  synthesis of indoles that are structurally related to the Aplysinopins.


Jones, Richard C., Ph.D., Associate Professor

B.A. in Geology, West Virginia University
M.A.T. in Geology, University of Texas at Dallas
Ph.D. in Curriculum and Instruction-Science, Texas A&M University

Office: ASSC 335
Telephone: 940.898.2557
email: RJones2@mail.twu.edu

Primary Teaching Area:Science and Science Education

Research Interests:  Science Education


Maguire, Cynthia, Lecturer II

Maguire, Cynthia, Lecturer II

B.S. in Medical Technology, Central State University, Edmond OK
M.S. in Biology, Texas Woman's University
M.S. in Chemistry, Texas Woman's University

Office: ASSC 337
Telephone: 940 898-2563
email: CMaguire@mail.twu.edu

Primary Teaching Area: Science core courses and general chemistry.

Research Interests:  Science education and sustainability issues, particularly water.  

I want to know more about how TWU science core courses can improve science learning among non-science majors. Several of our SCI prefix courses follow the SENCER guidelines (see http://www.sencer.net ) designed to generate better retention of science knowledge. Our work is partially supported by grants from the National Center for Science and Civic Engagement (see http://www.ncsce.net ).


NasrinMirsaleh-Kohan, Nasrin, Ph. D

Ph.D. in Chemical Physics, University of Tennessee
M.S. in Physics, Bowling Green State University
B.S. in Physics, University of Tehran, Iran

Office:  ASSC 327
Telephone: 940 898-2035
email: nmirsalehkohan@mail.twu.edu

Primary Teaching Area:  Physics

Research Interests: Interaction of anticancer drugs with DNA

 In most cancer treatments chemotherapeutic drugs are combined with radiation therapy. Clinical studies demonstrate concomitant treatment with anticancer drugs and radiotherapy often leads to a higher rate of survival and local tumor control. However, the nature of interaction of these drugs with DNA is not very well understood. The goal of our research group is to develop a spectroscopic model to understand the nature of interaction of anticancer drugs with DNA employing surface-enhanced Raman scattering (SERS). SERS, a phenomenon that occurs on a nanoscale-roughened metallic surface, has attracted considerable attention for both in vitro and in vivo medical diagnostics.  Our group uses laser spectroscopic techniques such as Raman and SERS along with theoretical calculations to examine and interpret the interaction of anticancer drugs with DNA at the molecular level.

 


 

Peebles, Lynda, Ph.D., Lecturer II

Peebles, Lynda, Ph.D., Senior Lecturer

B.S. in Chemistry, Harding University
Ph.D. in Physical Chemistry, University of North Texas

Office: ASSC 331
Telephone: 940.898.2556
email: LPeebles@mail.twu.edu

Primary Teaching Area: Introductory Chemistry, Introduction to Organic and Physiological Chemistry, Physical Chemistry

Research Interests:  Chemical Education


Rawashdeh-Omary, Manal, Ph.D., Assistant Professor

Rawashdeh-Omary, Manal, Ph.D., Assistant Professor

B.S. in Chemistry, Yarmouk University
Ph.D. in Inorganic Chemistry, University of Maine

Office: GRB 326
Telephone: 940.898.2565
Lab:  940.898.2477
email: MOmary@mail.twu.edu

Primary Teaching Area:Inorganic and Analytical Chemistry

Research Interests:Synthesis and characterization of novel new molecular materials, including metallopolymers and small-molecule transition metal and lanthanide complexes that have the potential for being used in applications such as: Polymer light-emitting diodes, PLEDs, Solar energy conversion (Organic Photovoltaics, OPVs), Probes for biological systems, Optical sensors for environmental pollutants


Riggs, Charles, Ph.D., Professor

B.S. in Chemistry and Mathematics, Southwestern State College, OK
Ph.D. in Chemistry, Oklahoma State University

Office: ASSC 328
Telephone: 940.898.2670
Lab: OMB 404B
email: CRiggs@mail.twu.edu

Primary Teaching Area:Chemistry and Textiles

Research Interest:  Colloidal Chemistry and Textile Polymers


Sheardy, Richard, Ph. D., Professor and ChairSheardy, Richard, Ph. D., Professor and Chair

B.S in Chemistry
M.S in Chemistry
Ph.D. in Organic Chemistry

Office: ASSC 323
Telephone: 940.898.2551
Lab: GRB 315/316
Lab phone: 940 898-2547
email: rsheardy@mail.twu.edu

Primary Teaching Area: Biochemistry

Research Interest:  Our research focuses on the conformational properties of nucleic acids:  conformation, conformational transitions, ligand binding, and the thermodynamics associated with conformation, conformational transitions and binding. We are primarily interested in how sequence context and environmental conditions influence these properties.  We use a variety of biophysical techniques such as UV/Vis and circular dichroism spectroscopies, differential scanning calorimetry and isothermal titration calorimetry.

Although the Watson-Crick model of DNA as a right-handed double helical structure stands as the primary conformation in how we think about DNA, we now know that DNA is highly polymorphic: (A) DNA can exist as a single strand, duplex, triplex, quadruplex or even multiplex; (B) the duplex can either be right handed of left handed; and, (C), DNA can be sculpted into unusual higher order structures.  Ultimately, the conformation and associated conformational properties of a segment of DNA is determined not only by its sequence context but also by the environmental conditions (i.e., temperature, pH, identity of counter ions and their concentrations, etc) under which it is prepared.  Of particular interest recently are the structures formed from G-rich DNAs designated as quadruplexes. DNA sequences that have islands of G2-4 separated by 1 to 4 A or T bases can form a rich library of secondary structures with different molecularities, strand orientations, and guanine base conformation (i.e., syn or anti).  Thus, we are investigating the structure, stability and ligand binding of DNA quadruplexes.

page updated 8/25/2014 11:57 AM

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