Anderson, Mary, Ph.D., Associate Professor
B.A. in Chemistry, Hollins College
Ph.D. in Biochemistry, Cornell University Graduate School of Medical Sciences
Office: ASSC 329
Lab: GRB 207
Primary Teaching Area: Biochemistry
Research Interests: My research team study enzymes, mainly the homodimeric glutathione synthetase, important in the biosynthesis of the body’s most important natural antioxidant, glutathione. Experimental and computational techniques are integrated to understand how this key enzyme works. Glutathione protects against many things (toxins and aging). Diseases such as HIV, Parkinson’s and Alzheimer’s are associated with glutathione deficiencies. My research team (undergraduate and graduate students) work on increasing knowledge of protein-protein interactions, designing better enzymes and therapies for glutathione deficiency.
B.S. in Chemistry, Millsaps College
Ph.D. in Chemistry, University of Oregon
Office: GRB 203B
Lab: GRB 203
Primary Teaching Area:Physical Biochemistry
Research Interests:Our research investigates the role played by the bulk enzyme structure in the enzyme catalytic event. Specifically we are testing a hypothesis, the Shifting Specificity Model, to explain enzyme catalysis generally. Our experiments involve kinetic and thermodynamic measurements of interactions of enzymes with catalytically relevant ligands.
B.S. in General Science - Chemistry, Mississippi State University
Ph.D. in Organic Chemistry, Mississippi State University
Primary Teaching Area: General Chemistry
Research Interests: Chemical Education
B.S. in Chemistry, University of Minnesota
M.S. in Chemistry, University of Minnesota
Ph.D. in Organic Chemistry, University of Missouri, Columbia
Office: GRB 103
Labs: GRB 108, 112, 205, 211, 213, and 215
Primary Teaching Area: Organic Chemistry
Research Interests: Chemistry of organic nitrogen compounds: mechanisms of nucleophilic substitution reactions on the carbon-nitrogen double bond; mechanisms of Z/E isomerization of compounds containing a carbon-nitrogen double bond (photochemical, thermal, acid- and base-catalyzed); synthesis of hydroximoyl halides, hydroximates, thiohydroximates, amidoximes, oximes, and other compounds containing a carbon-nitrogen double bond; photochemical reactions of amides, alkyl benzohydroxamates, and other structurally related organic nitrogen compounds; synthesis of indoles that are structurally related to the Aplysinopins.
B.A. in Geology, West Virginia University
M.A.T. in Geology, University of Texas at Dallas
Ph.D. in Curriculum and Instruction-Science, Texas A&M University
Office: ASSC 335
Primary Teaching Area:Science and Science Education
Research Interests: Science Education
B.S. in Medical Technology, Central State University, Edmond OK
M.S. in Biology, Texas Woman's University
M.S. in Chemistry, Texas Woman's University
Office: ASSC 337
Telephone: 940 898-2563
Primary Teaching Area: Science core courses and general chemistry.
Research Interests: Science education and sustainability issues, particularly water.
I want to know more about how TWU science core courses can improve science learning among non-science majors. Several of our SCI prefix courses follow the SENCER guidelines (see http://www.sencer.net ) designed to generate better retention of science knowledge. Our work is partially supported by grants from the National Center for Science and Civic Engagement (see http://www.ncsce.net ).
Mirsaleh-Kohan, Nasrin, Ph. D
Ph.D. in Chemical Physics, University of Tennessee
M.S. in Physics, Bowling Green State University
B.S. in Physics, University of Tehran, Iran
Office: ASSC 327
Telephone: 940 898-2035
Primary Teaching Area: Physics
Research Interests: Interaction of anticancer drugs with DNA
In most cancer treatments chemotherapeutic drugs are combined with radiation therapy. Clinical studies demonstrate concomitant treatment with anticancer drugs and radiotherapy often leads to a higher rate of survival and local tumor control. However, the nature of interaction of these drugs with DNA is not very well understood. The goal of our research group is to develop a spectroscopic model to understand the nature of interaction of anticancer drugs with DNA employing surface-enhanced Raman scattering (SERS). SERS, a phenomenon that occurs on a nanoscale-roughened metallic surface, has attracted considerable attention for both in vitro and in vivo medical diagnostics. Our group uses laser spectroscopic techniques such as Raman and SERS along with theoretical calculations to examine and interpret the interaction of anticancer drugs with DNA at the molecular level.
B.S. in Chemistry, Harding University
Ph.D. in Physical Chemistry, University of North Texas
Office: ASSC 331
Primary Teaching Area: Introductory Chemistry, Introduction to Organic and Physiological Chemistry, Physical Chemistry
Research Interests: Chemical Education
B.S. in Chemistry, Yarmouk University
Ph.D. in Inorganic Chemistry, University of Maine
Office: GRB 326
Primary Teaching Area:Inorganic and Analytical Chemistry
Research Interests:Synthesis and characterization of novel new molecular materials, including metallopolymers and small-molecule transition metal and lanthanide complexes that have the potential for being used in applications such as: Polymer light-emitting diodes, PLEDs, Solar energy conversion (Organic Photovoltaics, OPVs), Probes for biological systems, Optical sensors for environmental pollutants
B.S. in Chemistry and Mathematics, Southwestern State College, OK
Ph.D. in Chemistry, Oklahoma State University
Office: ASSC 328
Lab: OMB 404B
Primary Teaching Area:Chemistry and Textiles
Research Interest: Colloidal Chemistry and Textile Polymers
B.S in Chemistry
M.S in Chemistry
Ph.D. in Organic Chemistry
Office: ASSC 323
Lab: GRB 315/316
Lab phone: 940 898-2547
Primary Teaching Area: Biochemistry
Research Interest: Our research focuses on the conformational properties of nucleic acids: conformation, conformational transitions, ligand binding, and the thermodynamics associated with conformation, conformational transitions and binding. We are primarily interested in how sequence context and environmental conditions influence these properties. We use a variety of biophysical techniques such as UV/Vis and circular dichroism spectroscopies, differential scanning calorimetry and isothermal titration calorimetry.
Although the Watson-Crick model of DNA as a right-handed double helical structure stands as the primary conformation in how we think about DNA, we now know that DNA is highly polymorphic: (A) DNA can exist as a single strand, duplex, triplex, quadruplex or even multiplex; (B) the duplex can either be right handed of left handed; and, (C), DNA can be sculpted into unusual higher order structures. Ultimately, the conformation and associated conformational properties of a segment of DNA is determined not only by its sequence context but also by the environmental conditions (i.e., temperature, pH, identity of counter ions and their concentrations, etc) under which it is prepared. Of particular interest recently are the structures formed from G-rich DNAs designated as quadruplexes. DNA sequences that have islands of G2-4 separated by 1 to 4 A or T bases can form a rich library of secondary structures with different molecularities, strand orientations, and guanine base conformation (i.e., syn or anti). Thus, we are investigating the structure, stability and ligand binding of DNA quadruplexes.
page updated 1/3/2017 2:14 PM