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 Articles:

T. R. Brown, Drummond, M.L., Barelier, S., Crutchfield, A.S., Dinescu, A., Slavens, K.D., Cundari, T.R., and M.E. Anderson, “Aspartate 458 of Human Glutathione Synthetase is Important for Cooperativity and Active Site Structure”, Biochem. Biophys. Res. Commun., 411, 536-42, 2011.

K. A. Slavens, Brown, T.R., Barakat, K.A., Cundari, T.R., and M.E. Anderson, “Valine 44 and Valine 45 of Human Glutathione Synthetase are Key for Stability and Negative Cooperativity”, Biochem. Biophys. Res. Commun., Biochem. Biophys. Res. Commun., 410, 597-601, 2011.

Dinescu, A., Brown, T.R., Barelier, S., Cundari, T.R., and M.E. Anderson, “The Role of the Glycine Triad in Human Glutathione Synthetase”, Biochem. Biophys. Res. Commun., 400, 511-16, 2010.

Dinescu, A., Anderson, M.E. and Cundari, T.R. “Catalytic Loop Motion in Human Glutathione Synthetase: A Molecular Modeling Approach”, Biochem Biophys. Res. Communications, 353, 450-456, 2007. 

Dinescu, A., Cundari, T.R., Bhansali, V.S., Luo, J.-L., and Anderson, M.E., “Function of Conserved Residues of Human Glutathione Synthetase: Implications for the ATP-grasp Enzymes”, Journal of Biological Chemistry, 279:22412-21, 2004.

Njalsson, R., Carlsson, K., Bhansali, V., Luo, J.-L., Nilsson, L., Ladenstein, R., Anderson, M., Larsson, A., and Norgren, S., “Human Hereditary Glutathione Synthetase Deficiency: Kinetic Properties of Mutant Enzymes”, Biochemical Journal, 381(Pt 2):489-94, 2004.

Njalsson, R., Norgren, S., Larsson, A., Huang, C.-s., Anderson, M.E, Luo, J.-L., “Cooperative Binding of g-Glutamyl Substrate to Human Glutathione Synthetase”, Biochem. Biophys, Res. Commun, 289, 80-84, 2001

Dalhoff, K., Laursen, H., Bangert, K., Poulsen, H.E., Anderson, M.E. and Grunnet, N. and N. Tygstrup, “Autoprotection in Acetaminophen Intoxication in Rats: The Role of Liver Regeneration”, Pharmacol. Toxicol 88, 135-141, 2001.

Kruse, P., Anderson, M.E. and Loft, S., “Minimum Signs of Oxidative Stress During Intermediate Acute Pancreatitis in Rats”, Free Radical Biology and Medicine 30, 309-317, 2001.

Luo, J-L, Huang, C-S, Babaoglu, K. and Anderson, M.E., “Novel Kinetics of Mammalian Glutathione Synthetase: Characterization of g-Glutamyl Substrate Cooperative Binding”, Biochem. Biophys. Res. Commun. 275, 577-581, 2000.

M.E. Anderson and Luo, J.L., “Glutathione Therapy: From Prodrugs to Genes”, Seminars in Liver Disease 18, 415-424, 1998.

M.E. Anderson. “Glutathione: an overview of biosynthesis and modulation”, Chemico-Biological Interactions 111-112, 1-14, 1998.

Hochwald, S.N,, Harrison, L.E., Anderson, M.E., Rose, D.M., and Burt, M.E., “g-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization”, J Natl. Cancer Inst 88, 193-107, 1996.

Ikeda, Y. Fujii, J., Anderson, M.E., Taniguchi, N. and Meister, A., “Involvement of Ser-451 and -452 in the Catalysis of Human g-Glutamyl Transpeptidase”, J. Biol.  Chem. 270, 22223-22228, 1995.
Huang, C.-S., He, W., Meister, A., and Anderson, M.E.: “Glutathione Synthetase” Proc. Natl. Acad. Sci. 92, 1234-1236, 1995.

S. Boesgaard, J. Aldershvile, H.E. Poulsen, S. Loft, M.E. Anderson, and A. Meister: “Nitrate Tolerance In Vivo Is Not Associated with Depletion of Arterial or Venous Thiol Levels”, Circulation Research, 74, 115 120, 1994.

E.J. Levy, M.E. Anderson, and A. Meister: “Transport of Glutathione Diethyl Ester into Human Cells”, Proc. Natl. Acad. Sci., 90, 9171-9175, 1993.

E.J. Levy, M.E. Anderson, and A. Meister: “On the Synthesis and Characterization of N-Formyl Glutathione and N-Acetyl Glutathione”, Anal. Biochem., 214, 135-137,1993.

C.-s. Huang, Long-sen Chang, M.E. Anderson, and A. Meister: “Amino Acid Sequence and Function of the Light Subunit of Rat Kidney g-Glutamylcysteine Synthetase”, J. Biol. Chem., 268, 20578-20583, 1993.

C.-s. Huang, M.E. Anderson, and A. Meister: “Catalytic and Regulatory Properties of the Heavy Subunit of Rat Kidney 0-Glutamylcysteine Synthetase, Journal of Biological Chemistry, 268, 19675-19680, 1993.

S. Boesgaard, H.E. Poulsen, J. Aldershvile, S. Loft, M.E. Anderson, and A. Meister: “Acute Effects of Nitroglycerin Depend on Both Plasma and Intracellular Vascular Sulfhydryl Compound Levels In Vivo.  Effect of  Agents with Different Sulfhydryl Modulating Properties”, Circulation 87, 547-553, 1993.

A.K. Godwin, A. Meister, P.J. O’Dwyer, C.-S. Huang, T.C. Hamilton, and M.E. Anderson: “High Resistance to Cisplatin in Human Ovarian Cancer Cell Lines is Associated with Marked Increase of Glutathione Synthesis”, Proc. Natl. Acad. Sci, 89, 3070-3074, 1992.

T. Kalebic, A. Kinter, G. Poli, M.E. Anderson, A. Meister, and A.S. Fauci: “Suppression of HIV Expression in Chronically Infected Monocytic Cells by Glutathione, Glutathione Ester, and N-Acetyl Cysteine”, Proc. Natl. Acad. Sci., U.S., 88, 896-990, 1991.

M.E. Anderson, A. Naganuma, and A. Meister: “Protection Against Cisplatin Toxicity By Administration of Glutathione Ester”, FASEB Journal, 4 (14), 3251-3255, 1990.

Naganuma, M.E. Anderson, and A. Meister: “Cellular Glutathione is a Determinant of Sensitivity to Mercuric Chloride Toxicity; Prevention of Toxicity by Giving Glutathione Monoester”, Biochemical Pharmacology, 40, 693-697,1990.

M. Suthanthiran, M.E. Anderson, V. K. Sharma, and A. Meister: “Glutathione Regulates Activation-Dependent DNA Synthesis in Highly Purified T lymphocytes stimulated via CD2 and CD3 Antigens”, Proc.  Natl. Acad. Sci., U.S., 87, 3343-3347, 1990.

M.E. Anderson, A. Meister, “Glutathione Monoesters”, Anal Biochem 183, 16-20, 1989.
M.E. Anderson, M. Underwood, R.J. Bridges and A. Meister: “Glutathione Metabolism at the Blood-Cerebrospinal Fluid Barrier”, FASEB Journal 3, 2527-2531, 1989.

W.R. Moore, M.E. Anderson, A. Meister, K. Murata and A. Kimura: “Increased Capacity for Glutathione Synthesis Enhances Resistance to Radiation in Escherichia coli: A Possible Model for Mammalian Cell Protection, Proc Natl. Acad Sciences, 86, 1461-1464, 1989.

M.E. Anderson and A. Meister: “2-Oxo-thiazolidine-4-carboxylic acid and Mouse Brain Cysteine and Glutathione Levels”, FASEB Journal 3, 1632-1636, 1989.

M.B. Astor, M.E. Anderson, Meister, A.: “Relationship Between Intracellular GSH Levels and Hypoxic Cell Radiosensitivity”, J. Pharm.  Therapeutics, 39, 115-121, 1988.

R.K. Singhal, M.E. Anderson and A. Meister: “Glutathione, a First Line of Defense Against Cadmium Toxicity”, FASEB Journal 1, 220-223, 1987.

M.E. Anderson and A. Meister: “Intracellular-Delivery of Cysteine”, Methods in Enzymology 143, 313 325, 1987.

M.E. Anderson and A. Meister: “Inhibition of g-Glutamyl Transpeptidase and Induction of Glutathionuria by g-Glutamyl Amino Acids”, Proc. Natl. Acad. Sci, 83, 5029-32, 1986.

A. Meister, M.E. Anderson and 0. Hwang: “Intracellular Cysteine and Glutathione Delivery Systems”, Journal of the American College of Nutrition, 5, 137-157, 1986.

Anderson, M.E., F. Powrie, R.N. Puri and A. Meister: “Glutathione Monoethyl Ester: Preparation, Uptake by Tissues, and Conversion to Glutathione”, Archives of Biochem. Biophys, 239, 538-548, 1985.

V.P. Wellner, M.E. Anderson, R.N. Puri, G.L. Jensen and A. Meister: “Radioprotection by Glutathione Ester; Transport of Glutathione Ester into Human Lymphoid Cells and Fibroblasts”, Proc.  Natl.  Acad, Sci.  U.S., 81, 4732-4735, 1984.

M.E. Anderson and A. Meister: “Transport and Direct Utilization of g-Glutamylcyst(e)ine for Glutathione Synthesis”, Proc. Natl. Acad.  Sci., U.S., 80, 707-711, 1983.

M.E. Anderson, R.D. Allison and A Meister: “Interconversion of Leukotrienes Catalyzed by Purified g Glutamyl Transpeptidase: Concomitant Formation of Leukotriene D4 and g-Glutamyl Amino Acids”, Proc.  Natl.  Acad.  Sci., U.S., 79, 1088-1091, 1982.

R.L. Beamer, O.W. Griffith, J.D. Gass, M.E. Anderson and A. Meister: Interaction of L- and D-3Amino-l-chloro-2-pentanone with g-Glutamylcysteine Synthetase”, J. Biol. Chem. 255, 11,73211,736, 1980.

M.E. Anderson, R.J. Bridges and A. Meister: “Direct Evidence for Inter-Organ Transport of Glutathione and that the Non-Filtration Renal Mechanism of Glutathione Utilization Involves g-Glutamyl Transpeptidase”, Biochem Biophys Res Comm 96, 848-853, 1980.

M.E. Anderson and A. Meister: “Dynamic State of Glutathione in Blood Plasma”, Journal of Biological Chemistry 255, 9530-9533, 1980.

O.W. Griffith, M.E. Anderson, and A. Meister: “Inhibition of Glutathione Biosynthesis by Prothionine Sulfoxjmine (S-n-Propyl Homocysteine Sulfoximine), A Selective Inhibitor of g-Glutamylcysteine Synthetase”, J. Biol.  Chem. 2 54, 1205-1210, 1979.

Book Chapters and Chapters in Series:

Larsson, A., Ristoff, E. and Anderson, M.E., “Glutathione Synthetase Deficiency and Other Disorders of the g-Glutamyl Cycle” in: Metabolic Basis of Inherited Disease, Online (genetics.accessmedicine.com) (eds. Scriver, C.R., Beaudet, A.L., Sly, W.S and Valle, D.) McGraw Hill, NY, 2005

Larsson, A. and Anderson, M.E., “Glutathione Synthetase Deficiency and Other Disorders of the g Glutamyl Cycle” in: Metabolic Basis of Inherited Disease, 8th ed. (eds. Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D.) McGraw Hill, NY, pp. 2205-16, 2001.

Anderson, M.E.: “Modulation of Glutathione”; in Handbook of Synthetic Antioxidants, eds.  Packer, L. and Cadenas, E., pp. 321-338, 1997, Marcel Dekker, Inc.

Anderson, M.E.: “Glutathione”; in Free Radicals a Practical Approach, eds.  Punchard, N.A. and Kelly, F.J., Oxford University Press, New York, pp.213-226, 1996.

Anderson, M.E.: “Glutathione and Glutathione Delivery Compounds”; Advances in Pharmacology 38, 65 78, 1997.

E.J. Levy, M.E. Anderson, and A. Meister: “Preparation and, Use of Glutathione Diesters”, Methods in Enzymology, 504-511, 1994.

M.E. Anderson, E.J. Levy, and A. Meister: “Preparation and Use of Glutathione Monoesters”, Methods in Enzymology, 511-517, 1994.

M.E. Anderson: “Enzymatic and Chemical Methods for the Determination of Glutathione”, in Coenzymes and Cofactors: Glutathione, D. Dolphin, R. Poulson, and 0. Avramovic, eds, John Wiley, New York, pp. 339-366,1989.

M.E. Anderson: “Determination of Glutathione and Glutathione Disulfide in Biological Samples” Methods in Enzymology, 113, 548-555, 1985.

M.E. Anderson and A. Meister: “Preparation of g-Glutamyl Amino Acids by Chemical and Enzymatic Methods”, Methods in Enzymology 113, 555-564, 1985.

M.E. Anderson: “Determination of Glutathione in Biological Tissues”, Handbook for Oxygen Radical Research (A.  Greenwald, Ed.), CRC Press, Boca Raton, Fla., 317-323, 1985.

A. Meister and M.E. Anderson: “Glutathione”, Annual Reviews of Biochemistry, 52, 711-760, 1983.

Patents

US #6,127,165, Rat glutathione synthatase gene; C-s Huang, A Meister, ME Anderson

US # 5,869,456, Use of glutathione diesters; E.J. Levy, M.E. Anderson, A. Meister

US #  5,747,329, Glutamylcysteine synthetase light subunit; C.-s. Huang, M.E. Anderson, A. Meister

US #  5,476,966, Method for depletion of glutathione; M.E. Anderson and A. Meister

US # 5,464,825, Raising glutathione equivalent levels using N-acyl glutathione monoesters; E.J. Levy, M.E. Anderson, A. Meister

US #4,758,551, Methods for combatting renal toxicity due to metals or nephrotoxic drugs and for selectively modulating in vivo formation of leukotriene types; M.E. Anderson, A. Meister

Presentations at Professional Meetings: (Abstracts since 1998 - current)

Thomas R. Cundari and Mary E. Anderson “Catalyst Design: What Can We Learn from Enzymes and Bilogical Modeling?” VIth International Workshop on Quantum Systems in Chemistry and Physics (QSCP-XVI), Kanazawa, Japan, September 2011.

T. Brown, K. Slavens, M. DeJesus, A. Crutchfield, B. Shrestha, M.L. Drummond, S. Barelier, A. Dinescu, T.R. Cundari, M.E. Anderson. “Function of Aspartate 458 in Human Glutathione Synthetase”, American Society for Biochemistry and Molecular Biology Annual Meeting, April 2011 Washington, D.C. [T. Brown, Graduate Student Travel Award from ASBMB].

K. Slavens, B. Shrestha,T. Brown, K. Barakat, T.R. Cundari , and M.E. Anderson. “Glutathione Synthetase: Hydrophobic Interactions and Stability”, American Society for Biochemistry and Molecular Biology Annual Meeting, April 2011 Washington, D.C.

 A. Crutchfield, T. Brown, K. Slavens, M. De Jesus, A. Graves, B. Shrestha, A. Dinescu, S. Barelier, T.R. Cundari, and M.E. Anderson, “Analysis of Aspartate 458 in the A Loop of Glutathione Synthetase”, ACS SWRM meeting, October 2011, Austin

T.R. Cundari and M.E. Anderson, “Role of Catalytic Loops in Glutathione Synthetase Negative Cooperativity”, ACS SWRM meeting, October 2011, Austin

K. Selman, M. De Jesus, T.R.Cundari, M.E. Anderson, Glutathione Synthetase: Dimer Interface and Negative Cooperativity March 2010 San Francisco ACS National meeting

T. Brown, S. Barelier, A. Dinescu, T.R. Cundari, M.E. Anderson, The A-loop of Human Glutathione Synthetase; March 2010 San Francisco ACS National meeting

T. Brown, A. Dinescu, K. Slavens, M. DeJesus, T.R. Cundari, M.E. Anderson, Unusal Glycine Triad Key for GSH Synthetase Activity, poster to be presented at the national meeting of the American Society of Biochemistry and Molecular Biology, New Orleans, LA., April 17-22, 2009.

M.E.Anderson, T. Brown, S. Barelier, A. Dinescu, T.R. Cundari, C-Terminal Residues of Glutathione Synthetase: A Mutational Analysis, poster at the Southwest Regional American Chemical Society Meeting in Little Rock, October 1 to 4, 2008.

T. Brown, S. Barelier, A. Dinescu, T.R. Cundari,  M.E. Anderson, C-Terminal Residues of Glutathione Synthetase, poster at the American Society of Biochemistry and Molecular Biology National meeting, April 2008 [note: T. Brown received an Undergraduate Research Achievement Award Poster Competition, and a Undergraduate Competitive Travel Award.

K. Selman, T.Brown, A. Dinescu, M.E. Anderson, Substrate Loop in Glutathione  Synthetase: a mutational analysis, poster at the American Society of Biochemistry and Molecular Biology National meeting, April 2008.

T. Brown, Sarah Barelier, Adriana Dinescu, T. R. Cundari, M.E. Anderson, C-Terminal Residues of Human Glutathione Synthetase: A Mutational Study, Platform Oral presentation at the Dallas Fort Worth American Chemical Society Meeting-in-Miniature April 2008. Undergraduate [note: T. Brown received 3rd place award of excellence in the undergraduate division.

K. Selman, T. Brown, M.E. Anderson; Glutathione Synthetase: Substrate Loop Mutational Analysis, poster at the Student Research Symposium at Texas Woman’s University, April 2008.

T. Brown, A. Dinescu, Sarah Barelier, T. Cundari, M.E. Anderson ; C-Terminal Interactions of Human Glutathione Synthetase,  poster at the Student Research Symposium at Texas Woman’s University, April 2008.

M.E. Anderson. S. Hernandez, M.J. Carter, T.R. Cundari, A. Dinescu, S. Barelier, “Modeling of Human Glutathione Synthetase: An ATP-Grasp Enzyme”, Talk at the Southwest Regional Meeting of the American Chemical Society in Lubbock, TX, November 2007.

M.E. Anderson, T.R. Cundari, A. Dinescu, M. Carter, S. Hernandez, “Modeling of human glutathione synthetase: An ATP-Grasp enzyme”, at the national meeting of the American Chemical Society in Chicago, March 2007.

T. Brown, A. Dinescu, T. Cundari, M.E. Anderson, “A-Loop Residues in Glutathione Synthetase” for the national meeting of the American Society of Biochemistry and Molecular Biology in Washington, D.C., April 2007.

M.Carter, K. Barakat, T.R. Cundari, and M.E. Anderson, "Subunit Interactions of Human Glutathione Synthetase", the national meeting of the American Society of Biochemistry and Molecular Biology in Washington, D.C., 2007.

K.Selman, T.Brown, A.Dinescu. M.E. Anderson, T. Cundari Human, "Glutathione Synthetase Substrate Loop Analysis",  for the national meeting of the American Society of Biochemistry and Molecular Biology in Washington, D.C., 2007.

A. Dinescu, T.R. Cundari, and M.E. Anderson, "Loop Interaction in Human Glutathione Synthetase" at the national meeting of the American Society of Biochemistry and Molecular Biology in San Francisco, 2006.

T. Brown, V. Bhansali, M.E. Anderson, “Site-Directed Mutagenesis Studies of Human Glutathione Synthetase” at American Chemical Society’s Meeting in Miniture, 2006.

T. Brown, V. Bhansali, and M.E. Anderson, “Site-Directed Mutagenesis Studies of Human Glutathione Synthetase”, at the Texas Woman's University Student Creative Arts and Research Symposium, 2006.

J. Castano, V. Bhansali, T. Brown, J. Koo, and M. E. Anderson , “Analysis of Conserved Region of Glutathione Synthetase” at the Texas Woman's University Student Creative Arts and Research Symposium, 2006.

J. Koo, V. Bhansali, T. Brown, J. Castano, M.E. Anderson, "Role of Conserved loop residues of human glutathione synthetase", at the Texas Woman's University Student Creative Arts and Research Symposium, 2006.

T. Brown, V. Bhansali, and M.E. Anderson, “Site-Directed Mutagenesis Studies of Human Glutathione Synthetase”, at the national meeting of the American Society of Biochemistry and Molecular Biology in San Francisco, 2006.

J. Castano, V. Bhansali, T. Brown, J. Koo, and M. E. Anderson , “Analysis of Conserved Region of Glutathione Synthetase” at the national meeting of the American Society of Biochemistry and Molecular Biology in San Francisco, 2006.

A. Dinescu, V. Bhansali, M.E. Anderson, T.R. Cundari: “Analysis of catalytic loops in human glutathione synthetase”, presented at the American Society of Biochemistry and Molecular Biology meeting, San Diego, 2005.

V. S. Bhansali, A. Dinescu, T.R. Cundari, M.E. Anderson: “Human Glutathione Synthetase: Studies of the Lid Domain”, presented at the American Society of Biochemistry and Molecular Biology meeting, San Diego, 2005.

V. S. Bhansali, R.Njålsson, K.Carlsson, J.L.Luo, A. Larsson, S. Norgren, M.E. Anderson: “Kinetic Properties of Mutant Enzymes in Glutathione Synthetase Deficiency”, presented at the American Society of Biochemistry and Molecular Biology meeting, Boston, 2004.

A. Dinescu, M.E. Anderson, T.R. Cundari: Analysis of Catalytic Loops in Human Glutathione Synthetase" for the Southwest Regional American Chemical Society meeting in Fort Worth, 2004.

A. Dinescu, T.R. Cundari, M.E. Anderson, V. Bhansali, “Function of conserved residues of human glutathione synthetase: Implications for the ATP-grasp enzymes”, for the American Society of Biochemistry and Molecular Biology, meeting, Boston, 2004.

V.Bhansali, R.Njålsson, K.Carlsson, J.L.Luo, A.Larsson, S.Norgren, M.E.Anderson, “Kinetic Properties of Mutant Enzymes in Glutathione Synthetase Deficiency”,  for the American Society of Biochemistry and Molecular Biology meeting, Boston, 2004.

A. Dinescu, T.R. Cundari, M.E. Anderson, V. Bhansali, “Function of conserved residues of human glutathione synthetase.  Implications for the ATP-grasp superfamily”, for the American Chemical Society meeting, Anaheim, 2004.

V. Bhansali, J.L. Luo, T.R. Cundari, and M.E. Anderson, “Experimental and Modeling Studies on the Function of Residues Near Substrate Binding Domains of Human Glutathione Synthetase”, presented The American Society of Biochemistry and Molecular Biology (ASBMB) meeting in San Diego, 2003.

J.-L. Luo and M.E. Anderson, “Negative Cooperativity of  Substrate Binding in Human Glutathione Synthetase”, presented at The American Society of Biochemistry and Molecular Biology (ASBMB) meeting in New Orleans, 2002.

Luo, J-L and Anderson, M.E.: “Kinetic Study on Key Residues of Mammalian Glutathione Synthetase ATP Binding Pocket”, presented at The American Society for Biochemistry and Molecular Biology (ASBMB) meeting, Orlando 2001.

Babaoglu, K, Luo, J.-L., Huang, C.-S, and M.E. Anderson, “Cooperative Binding and Mutations of the Binding Domain in Rat Glutathione Synthetase”, presented at The American Society for Biochemistry and Molecular Biology (ASBMB) meeting, Boston 2000.

M.E. Anderson, two talks on glutathione metabolism, International Conference on Inborn Errors of Metabolism: Workshop on the Inborn Errors of the g-Glutamyl Cycle; 1998, York, England.
M.E. Anderson, poster on glutathione, FASEB Summer Research Conference on “Molecular and Biological Mechanisms of Antioxidant Action”, 1998, Copper Mountain.

M.E. Anderson, talk on glutathione levels, III International Congress of Pathophysiology, 1998, Lahti, Finland.

Leadership:

1-2011 to 12-2013, Alternate Councilor, Dallas-Fort Worth representative to the National American Chemical Society

2009, Past-Chair, Dallas-Fort Worth section (Regional) of the American Chemical Society

2008, Chair, Dallas-Fort Worth section (Regional) of the American Chemical Society

2007, Chair-Elect, Dallas-Fort Worth section of the American Chemical Society

2007, Conference Attendence-Invited: American Chemical Society Leadership Conference, January, Baltimore, MD

 

 

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