McIntire, Sarah A., Ph.D.
PO Box 425799
Texas Woman's University
Denton, TX 76204-5799
Office Location: GRB 230, Lab: OMB 411
Office Phone: 940-898-2352
Teaching Area: Microbiology, Advanced Genetics
Research Area: Plasmid biology; Helicobacter pylori
|PhD||University of Cincinnati||Microbiology|
Major Academic/Research Interest
We study the role of plasmid DNA in the biology of the microorganism, Helicobacter pylori, the causative agent of ulcers and gastritis. H. pylori is also associated with gastric cancer. My lab has determined the DNA sequence of multiple plasmids and shown that they carry portions of the H. pylori chromosome. Each plasmid carries a different segment of the chromosome, indicating, we believe, that the plasmids play a role in the recognized rearrangements of the H. pylori chromosome. Most investigators believe that the rearrangements (inversions, deletions, and insertions) are important in this microorganisms ability to evade the human immune system. My research over 30 years resulted in 4 book chapters, 10 invited presentations, 19 refereed publications and 39 abstracts of presentations at national/international meetings.
Quinones, M., J. Knesek, and S. A. McIntire. 2002. Sequence and gene expression analyses of plasmid pHPM8 from Helicobacter pylori reveal the presence of two operons with putative roles in plasmid replication and antibiotic activity. Plasmid 46:223-228.
Minnis, J., T. Taylor, J. Knesek, and S. A. McIntire. 1995. Characterization of a 3.5 kbp plasmid from Helicobacter pylori. Plasmid 34:22-36.
Courses and Teaching Responsibilities
BACT 3113: Students in the sciences clearly need a solid foundation of basic scientific knowledge. The goal of this course is to provide information that is directly relevant to the future professional lives of the students. In addition to the basic microbiology, this course is designed to train the student to think logically and apply the facts that are presented in the formal lectures.
On completion of this course the student should understand: the structure and metabolism of various types of microorganisms, including bacteria, viruses and fungi; the pathogenic properties and the nature of the diseases caused by these organisms; the means of sterilization and disinfection utilized in controlling microorganisms; the mechanisms of antimicrobial agents; basic mechanisms of the human immune system and its interaction with microorganisms; and hospital-acquired infections.
The laboratory course, BACT 3111, is a co-requisite.
BIOL 6734: This course is designed for doctoral students who have completed all other required courses in the degree plan. This is a literature-based course in which the students study the historical development of the science of genetics by discussing the published research in the field.
BACT 3113 General Microbiology taught Fall and Spring. Course covers the principles, classification, anatomy, reproduction, growth, metabolism and control of viruses, bacteria and fungi. Prerequisite 6 hours of Introductory Biology.
BIOL 6734 - Advanced Genetics taught every other year. A literature based course covering theory, experimental methods and data analysis in genetics. Prerequisite: BIOL 6513 and BIOL 6334.
page last updated 4/20/2015 3:40 PM